MASCO Corporation

HEALTH and WELLNESS

Meta-Analysis: Effects of Probiotic Supplementation on Lipid Profiles in Normal to Mildly Hypercholesterolemic Individuals.

Abstract
INTRODUCTION:
Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol.
OBJECTIVE:
To evaluate the effects of probiotics on human serum lipid levels, we conducted a meta-analysis of interventional studies.
METHODS:
Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed.
RESULTS:
Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference -0.17 mmol/L, 95% CI: -0.27 to -0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference -0.22 mmol/L, 95% CI: -0.30 to -0.13 mmol/L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-term (> 4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-term (≤ 4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains.
CONCLUSIONS:
In conclusion, this meta-analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

Effects of probiotics on participants for intervention studiesFig 1
Flow diagram of the selection of published articles on probiotics for the treatment of hyperlipidemia for inclusion in this meta-analysis.

Advertisements

Archives

Management Info:

Designed By: Storyberry Corporation

Powered By: Google Inc.

Privacy Policy: JDF Corporation

Terms of Use: BPF Corporation

Merchant Processor: Donation

RSS Health Topics

  • Nutrition – Facts | Health | Definition Terms
    NUTRITION. Food is comprised of nutrients that are classified by their role in the body: the energy-yielding macronutrients (carbohydrates, protein, and fat), the essential micronutrients (vitamins, minerals, and water), and numerous … Continue reading →
  • VARICOSE VEINS
    Definition Varicose veins are dilated, tortuous, elongated superficial veins that are usually seen in the legs. Description Varicose veins, also called varicosities, are mostly often on the legs, although they can be found in other parts of the body. Mostly they appear as lumpy, winding vessels just below the surface of the skin. There are three types of vei […]
  • Cryotherapy
    Cryotherapy Definition Cryotherapy is a technique that uses an extremely cold liquid or instrument to freeze and destroy abnormal skin cells that require removal. It is a freezing substance or … Continue reading →
  • Exercise Therapy
      Exercise Therapy Definition Exercises is physical activity that is planned, structured and repetitive for the purpose of conditioning any part of the body. Exercise is utilized to improve health, … Continue reading →
  • Coronary Heart Disease – Diagnosis and Treatments
    Coronary Heart Disease Methods of Diagnosis Your healthcare provider diagnoses coronary artery disease (atherosclerosis) based on your medical and family histories, a physical exam, or results from the following tests. … Continue reading →

Categories

Stat Counter

Hours & Info

+1-313-2747400 (Phone) +1-313-7924177 (Fax)
Lunch Break: 11am - 1pm

Other Phone Number(s)

+1-763-416-0228

RSS MASCO Construction

%d bloggers like this: